The Big 12 is widely regarded as an conference based around offensive success. Jake Trotter wrote an article for ESPN this morning investigating how the evolution of the spread offense has impacted the conference.
Coaches told ESPN that the two things that have transformed the league from being a run dominated league a decade ago are Mike Leach and the explosion of 7 on 7 passing leagues within the Big 12 recruiting pipeline.
From a statistical standpoint, taking a look at the top offenses in the country through week 10, you see that half of the conference's quarterbacks rank in the top 10 in passing yardage, and Kansas State quarterback, Collin Klein, leads the country in rushing touchdowns (24).
The premise of the article is Leach was hired in '99 by Bob Stoops (and then left for Texas Tech), Mark Mangino took the offense from the Sooners to the Jayhawks, and Art Briles took it from Tech (to Houston, then) to Baylor, etc...
You can read the article in its entirety here. It's a good quick read.